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Estrogen may cause dementia. Transsexuals suceptible?

According to Mark Espeland of Wake Forest U in Winston-Salem estrogen taken as HRT therapy by older women may be responsible for this group to become susceptible to dementia and cognitive decline.
What is the likelyhood of estrogen therapy for Harry Benjamin Syndrome people taking high doses of estrogen pre-operatively and then maintainance doses post-operatively causing the same problem in HBS?
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